(8R,9S,10R,13S,14S)-10,13-diméthyl-6-méthylidène-7,8,9,10,11,12,13,14,15,16-décahydro-3H-cyclopenta[a]phénanthrène-3,17(6H)-dione CAS NO.107868-30-4

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Min.Order: 1 Gram
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Available Specifications:
top(1-10)Gram1/Gram1USD

Product Details

Keywords

Exemestane
Exemestan
Aromasin

Quick Details

ProName: (8R,9S,10R,13S,14S)-10,13-diméthyl-6-m...
CasNo: 107868-30-4
Molecular Formula: C20H24O2
Appearance: White to light yellow crystal powder
Application: For research purposes only
DeliveryTime: One day
PackAge: Discreet packing ways as your requirem...
Port: Guangzhou;Shanghai;Shenzhen;HK
ProductionCapacity: 100 Kilogram/Day
Purity: 99.8%
Storage: Keep in a cool and dry place
Transportation: shipping by EMS,DHL,TNT,FEDEX,UPS or a...
LimitNum: 1 Gram
Moisture Content: 0%
Impurity: 0%

Superiority

competive advantages

1.rich experience

we specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of coroperation with them.

2.great quality,purity and favorable

good quality is one of our biggest secert to success;u can get the best quality and service from us.

3.safest and fastest delivery

we have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.fast and discreet shipment will be arranged to pass customs.

4.good package

unique ways to ship 10g to 100kg powders to your destination.we offer melting powder into liquid service and ship the liquid in special bottles.

5.great after-sales service

any questions or problems after receiving the product,pls feel free to contact us.problems would be solved immediately.

general comments:

we have professional team for package and shipment.unique ways to ship 10g to 100kg powders at one time to your country.our shipments are by ems,dhl,tnt,fedex,hkems,ups,etc for 25kg,between 25kg-200kg by air,over 200kg by sea.fast and secure shipment could be arranged for customs pass guaranteed.

our company has independent import and export authority,also has the certificate of importing and exporting pharmaceutical materials.at the same time we are developed manufactures with mass stock.

Details

Medical uses

Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy. US FDA approval was in October 2005.

Exemestane is also indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

For premenopausal women with hormone-receptor–positive breast cancer, adjuvant treatment with ovarian suppression plus the aromatase inhibitor exemestane, as compared with ovarian suppression plus tamoxifen, provides a new treatment option that reduces the risk of recurrence. The TEXT and SOFT trials demonstrated improved disease free survival in patients treated with exemestane and ovarian suppression compared to the tamoxifen and ovarian suppression group. Premenopausal women who receive ovarian suppression may now benefit from an aromatase inhibitor, a class of drugs that until now has been recommended only for postmenopausal women.

Pharmacology

Pharmacodynamics

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

Exemestane is an irreversible, steroidal aromatase inactivator of type I, structurally related to the natural substrate 4-androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.

Type II aromatase inhibitors such as anastrozole and letrozole, by contrast, are not steroids and work by interfering with the aromatase's heme.

A study conducted on young adult males found that the estrogen suppression rate for exemestane varied from 35% for estradiol (E2) to 70% for estrone (E1).

Pharmacokinetics

Exemestane is quickly absorbed from the gut, but undergoes a strong first-pass effect in the liver. Highest blood plasma concentrations are reached after 1.2 hours in breast cancer patients and after 2.9 hours in healthy subjects. Maximal aromatase inhibition occurs after two to three days. 90% of the absorbed substance are bound to plasma proteins. The liver enzyme CYP3A4 oxidizes the methylidene group in position 6, and the 17-keto group (on the five-membered ring) is reduced by aldo-keto reductases to an alcohol. Of the resulting metabolites, 40% are excreted via the urine and 40% via the feces within a week. The original substance accounts for only 1% of excretion in the urine. The terminal half-life is 24 hours.

FAQ

1. Can I get a free sample

Yes, but you have to pay the courier fee.

2. How to pay

We accept payments in the form of , MoneyGram, Bitcoin, etc.

3. What should I do if we don’t ship after payment

We are a formal company certified by LOOKCHEM Integrity, you can provide proof of payment to LOOKCHEM complaints.

4. How long after the payment can be shipped

We have stocked products that are shipped within 24 hours. If you need to customize the product, we will negotiate the delivery cycle.

5. How is the safety of transportation

We will choose the safest delivery method to ensure customs clearance and safety during transportation.

6. What kind of company is THETA BIO

In 2009, Dr Zhang Lin from Johns Hopkins University founded the theta Biological Laboratory. He is committed to the study of protein assimilation preparations.

In 2013,Dr Zhang Lin returned to China to work in MSD China, and continued to work on biopharmaceutical research and development.

In 2018,Dr Zhang Lin founded shaoyang Theta Biological Thechnology Co.,Ltd.

Business Scope:

Pharmaceutical intermediate

Biotechology development

Fine organic chemistry

Biopharmaceutical

History of the company

In 2009,Dr Zhang Lin from Johns Hopkins University founded the theta Biological Laboratory.He is committed to the study of protein assimilation preparations.